Grant opportunity · National Institutes of Health

Extracellular Vesicle Therapeutics for Regenerative Medicine (ExTReMe)

Award amount varies

About this opportunity

The National Center for Advancing Translational Science (NCATS) seeks to advance its mission by advancing research on extracellular vesicles (EVs) and their use as therapeutics in the field of regenerative medicine. The main objective of this program, Extracellular Vesicle Therapeutics for Regenerative Medicine (ExTReMe) , is to support the translation of EV-based therapeutics in regenerative medicine. EVs, like exosomes and microvesicles, are crucial mediators of intercellular communication, carrying diverse cargo like proteins, nucleic acids, and lipids. In regenerative medicine, EVs play a significant role by influencing cellular behaviors during tissue repair and regeneration. Due to their natural function in intercellular communication, EVs represent a novel, cell-free, therapeutic tool. EVs can be further engineered to deliver therapeutic agents or modulate signaling pathways involved in repair/regeneration. Areas of interest for ExTReMe could include, but are not limited to: direct EV therapy (stem cell-isolated EVs produced under GLP conditions, and stored as off-the-shelf therapies); designer EVs (personalized to the individual patient’s needs). Grant authorities that allow the National Center for Advancing Translational Science (NCATS) to forecast this opportunity are as follows: 42 U.S. Code § 287a - Cures Acceleration Network

Who may apply

Public and State controlled institutions of higher education, Small businesses, Private institutions of higher education, State governments, For profit organizations other than small businesses, County governments, Independent school districts, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education

Deadline

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