Grant opportunity · National Institutes of Health

Selective Precision Targeting (SPoT)

~$1,500,000 total

About this opportunity

The National Center for Advancing Translational Science (NCATS) seeks to advance its mission by establishing a new initiative called Selective Precision Targeting (SPoT) to determine a mechanism for precise and on-target therapeutic drug delivery to specific hard-to-reach locations within the human body using microphysiological systems (MPS). Targeted drug-delivery systems, including engineered nanoparticles, extracellular vesicles or focused ultrasound, are methods for delivering medications to a specific area of the body (organ, tissue, or cell) to increase the concentration of the drug in that area. Hard-to-reach locations in the body include the blood–brain barrier, central nervous system, placenta, retina, or a tumor. More specifically, the initiative goals are to: Optimize specific targeting of nanoparticle therapeutics to the target organ/cell of interest Assess biodistribution and off-target effects using a multi-organ microphysiological system Provide evidence of functional cargo activity Determine optimal route of administration Grant authorities that allow the National Center for Advancing Translational Science (NCATS) to forecast this opportunity are as follows: 42 U.S. Code § 287a - Cures Acceleration Network.

Who may apply

For profit organizations other than small businesses, Independent school districts, Public and State controlled institutions of higher education, Public housing authorities/Indian housing authorities, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Small businesses, State governments, County governments, Private institutions of higher education, Native American tribal organizations (other than Federally recognized tribal governments), Native American tribal governments (Federally recognized)

Deadline

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